Advantages of Tylosin and Sulfamethazine Compatibility

Tylosin tartrate  sulfamethazine soluble powder is a very good compound preparation. Many veterinarians do not know how to use the soluble powder product of this compound preparation. Not to mention some primary care veterinarian friends who have never even seen this product.

To understand this combination, let’s start with each drug in the prescription. There are two main drugs in this compound preparation veterinary drug product, one is tylosin tartrate and the other is sulfamethazine.

Tylosin tartrate

Tylosin tartrate belongs to the class of macrolides and is a rapid bacteriostatic agent. It mainly acts on the bacterial 50S ribosomal subunit, inhibiting bacterial protein synthesis by blocking transpeptidation and mRNA displacement, thereby exerting its antibacterial effect.

Its antibacterial spectrum is similar to that of erythromycin. In its sensitive antibacterial spectrum, it has the strongest effect on mycoplasma; in addition, it also has a good antibacterial effect on some anaerobic bacteria in the digestive tract, such as the one that causes chicken necrotizing enteritis. Clostridium capsularis.

Chicken drinking water is administered, and the withdrawal period for oral administration of tylosin tartrate is 1 day (refer to the 2010 edition of “The People’s Republic of China Veterinary Pharmacopoeia Guidelines for Use of Chemicals Volume” P51 “Tylosin tartrate soluble powder”). It is in full compliance with the requirements of food safety control standards for antibiotics.


Sulfamethazine belongs to the sulfonamide class of antibacterial drugs, and mainly acts as a slow bacteriostatic agent in the stationary phase of bacteria. It mainly inhibits the growth and reproduction of bacteria by blocking the folate metabolism of bacteria. In addition to antibacterial, it also has a good effect on coccidia and toxoplasma in pigs and chickens.

Therefore, although sulfamethazine has a weak effect on most Gram-positive bacteria and Gram-negative bacteria, it has a good effect on Pasteurella, Coccidia and Toxoplasma. Therefore, it is effective against respiratory and digestive tract infections caused by chicken coccidia and Pasteurella.

Chicken drinking water is administered, and the withdrawal period of oral sulfamethazine is 10 days (refer to P79 “Sulfamethazine Tablets” of the 2010 edition of “The People’s Republic of China Veterinary Pharmacopoeia Guidelines for Use of Chemical Drugs”). So, this is quite okay for chicken medicine and food safety.

The advantages of compound preparations

According to the above-mentioned different antibacterial mechanisms of tylosin tartrate and sulfamethazine, we can clearly see that the antibacterial effects of these two drugs together are synergistic. Therefore, the product of the compound preparation has a stronger and more effective antibacterial effect than the single preparation product of the two drugs.

The clinical application effect of the compound preparation of tylosin tartrate and sulfamethazine soluble powder is determined to be better than their respective single preparation products.

From the antibacterial spectrum of tylosin tartrate and sulfamethazine introduced above, it can be seen that the antibacterial spectrum of these two drugs is superimposed, enhanced and complementary. Tylosin tartrate has good effect on Mycoplasma, Pasteurella and anaerobic bacteria in digestive tract, and sulfamethazine has outstanding effect on Pasteurella, Coccidia and Toxoplasma. Therefore, after their compound preparation has become a product, it is mainly effective for the following clinical diseases of livestock and poultry than the single prescription.

1. The treatment of upper respiratory tract infections in livestock and poultry caused by Mycoplasma, Pasteurella, etc. is more accurate than that of unilateral preparation products with the same function.

2. It is used for the treatment of chicken digestive tract diseases such as enteritis and enterotoxicity caused by coccidia, Pasteurella and anaerobic bacteria, and the clinical effect is better than that of single preparation products.

3. For the treatment of pig toxoplasma disease, it is better than the unilateral preparation products with the same function.

4. The two main drugs in the compound preparation have strong dual antibacterial effects on the pathogen causing waterfowl serositis, and their therapeutic effect is better than that of the single preparation.

However, in actual veterinary diagnosis and treatment, the degree of mixed feeling in some cases is beyond the scope of action of tylosin tartrate sulfamethazine soluble powder. Moreover, this kind of situation is still more in the actual treatment work, which requires the combination of different products to form a “prescription”.

A good product has a good effect in a good side

Therefore, according to the actual diagnosis results of the disease in veterinary clinics, for the upper respiratory tract infectious diseases of livestock and poultry with severe mixed infection and difficult to treat, the soluble powder of tylosin tartrate sulfamethazine can be used in combination with tonic pain and high efficiency. treat.

Tylosin tartrate sulfamethazine soluble powder is compatible with acetaminophen, which can treat more refractory and easy to repeat poultry upper respiratory tract infections!

In clinical practice, for those intestinal diseases such as enteritis and enterotoxicity that are more difficult to treat, the combination of tylosin tartrate sulfamethazine soluble powder and dimenidazole can be used for treatment, and a better therapeutic effect can be obtained. . Of course, this prescription would be better if you add a little more  colistin sulfate  (separately).

Food Safety – Withdrawal Period

According to the withdrawal period of “Tylosin tartrate soluble powder” (1 day for chickens) and “Sulfamethazine tablets” (10 days for poultry) in the 2010 edition of the “Veterinary Pharmacopoeia of the People’s Republic of China Guidelines for Use of Chemicals Volume”, then When “Tylosin tartrate sulfamethazine soluble powder” is used to treat upper respiratory tract infections and digestive tract infections in chickens, the maximum 10-day withdrawal period can ensure the food safety requirements of animal products.

The 28-day withdrawal period written on the product manual of the compound preparation is because no withdrawal period research was done when it was originally developed, and according to the national policy on those who have not done withdrawal period research, the maximum withdrawal period is 28 days. The implementation of the period caused it to be like this. Because the withdrawal period for chickens of these two single drugs has now been clarified, the longest withdrawal period for the two single drugs is implemented: 10 days for chickens, which can meet the needs of food safety.

How to combine the compatibility, synergy, change the method of medication and other technical capabilities and experience, how to use a single drug, add two drugs and other simple traditional medical thinking, to understand the pharmacology, to understand the characteristics of preparations Be clear and bring up the ability to prescribe.

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