Aureomycin, alias chlorotetracycline, English: Aureomycin, Chlortetracycline; was discovered in the United States in 1945. In February 1948, the American Cyanamid Company applied for a patent for chlortetracycline. In the same year, Dr. Thomas Jukes began to study the application of chlortetracycline in animal production (chicken), which played a key role in the application of chlortetracycline. effect. In 1950, he began to carry out application research on a variety of animals. In the same year, he completed the identification of the molecule and structure of chlortetracycline and produced the original chlortetracycline powder – chlortetracycline hydrochloride. In April 1953, the FDA approved chlortetracycline for the prevention of animal disease.
The study of chlortetracycline in farmed animals was completed in 1954. Low doses of chlortetracycline can promote the growth of poultry, pigs, cattle and sheep, and at high doses, it can control chronic respiratory diseases in animals. In 1967, the first international standard for chlortetracycline hydrochloride was promulgated. Mass production first began in the United States in the 1880s. In 1995, the wide application of chlortetracycline in China was started.
Little knowledge of chlortetracycline hydrochloride
1. Characteristics of chlortetracycline hydrochloride
Golden yellow or yellow crystals; odorless, bitter in taste; the color becomes darker when exposed to light. This product is slightly soluble in water or ethanol, and almost insoluble in acetone, ether or chloroform.
2. Use of chlortetracycline hydrochloride
Medicated eye ointment for the treatment of conjunctivitis and trachoma; or as a veterinary drug for feed addition or animal diseases.
3. Pharmacological application of chlortetracycline hydrochloride
Chlortetracycline hydrochloride is a tetracyclic broad-spectrum antibiotic, and its efficacy on penicillin-resistant and Staphylococcus aureus is slightly stronger than that of tetracycline. It has strong inhibitory effect on Gram-positive and negative bacteria and chlamydia, mycoplasma (mycoplasma) and rickettsia. Now it is mainly used for the treatment of conjunctivitis, veterinary drugs are used in feed addition or animal diseases, suitable for pullorum, typhoid, swine bacterial enteritis and bacterial diseases of livestock such as paratyphoid, cholera, etc.